Quinolines and derivatives
Medchemexpress LLC LED209 | 245342-14-7 | 98.4% | 383.49 | 200 MG
LED209 is a potent and orally active small molecule inhibitor of the bacterial receptor QseC and a potent prodrug with high selectivity for QseC. It inhibits the binding of signaling molecules to QseC and exhibits antibacterial activity.
- Potent and orally active small molecule inhibitor of bacterial receptor QseC.
- Potent prodrug with high selectivity for QseC.
- Inhibits the binding of signaling molecules to QseC.
- Has antibacterial activity.
- Decreases biofilm formation in EAEC O104:H4 and multidrug-resistant clinical isolates of rUTIs.
- Reduces L. pneumophila replication.
- Protects mice against S. Typhimurium and F. tularensis murine infections.
eMolecules Ambeed (4-Formyl-phenyl)-carbamicacidtert-butylester 250mg 521412715 A164452 0 000 144072-30-0 MFCD06245541 221 256 C12H15NO3
Ambeed (4-Formyl-phenyl)-carbamicacidtert-butylester 250mg 521412715 A164452 0 000 144072-30-0 MFCD06245541 221 256 C12H15NO3
Medchemexpress LLC 2,8-Quinolinediol | 15450-76-7 | 99.7% | 161.16 | 50 G
2,8-Quinolinediol, also known as 2,8-Dihydroxyquinoline or 8-Hydroxycarbostyril, is a biochemical reagent used as a biological material or organic compound in life science research. This compound is intended for research use only.
- Biochemical reagent for various life science applications.
- Can be utilized as a biological material.
- Functions as an organic compound for research.
- Available for research use only.
eMolecules 2305-70-6 | 4-HYDROXYQUINOLINE-3-CARBONITRILE | AstaTech | MFCD07787027 | 170.171 | C10H6N2O | 97.000 | Oc1c(cnc2ccccc12)C#N | 1g | 112525467
4-HYDROXYQUINOLINE-3-CARBONITRILE | AstaTech | 2305-70-6 | MFCD07787027 | 170.171 | C10H6N2O | 97.000 | Oc1c(cnc2ccccc12)C#N | 1g | 112525467
Medchemexpress LLC B7-H2/ICOSLG Mouse 50ug
B7-H2/ICOSLG is an important ligand of the T cell receptor ICOS and mediates immune responses It acts as a costimulatory signal promoting T and B cell proliferation cytokine secretion and plasma cell differentiation B7-H2/ICOSLG Protein Mouse (HEK293 His) is the recombinant mouse-derived B7-H2/ICOSLG protein expressed by HEK293 with C-His labeled tag
Medchemexpress LLC Letrozole (Standard) | 112809-51-5 | C17H11N5 | 200 MG
Letrozole (CGS 20267) is a potent, selective, reversible, and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. It selectively inhibits estrogen biosynthesis and can be used for breast cancer research.
- Potent, selective, reversible, and orally active non-steroidal inhibitor of aromatase
- Selectively inhibits estrogen biosynthesis
- Used for breast cancer research
- Exhibits anti-tumor effects in rats
- Inhibits growth of MCF-7 epithelial breast cancer cells
eMolecules 74124-79-1 | N,N'-Disuccinimidyl carbonate | Chem-Impex | MFCD00009767 | 256.170 | C9H8N2O7 | 99.000 | O=C(ON1C(=O)CCC1=O)ON1C(=O)CCC1=O | 5kg | 342449122
N,N'-Disuccinimidyl carbonate | Chem-Impex | 74124-79-1 | MFCD00009767 | 256.170 | C9H8N2O7 | 99.000 | O=C(ON1C(=O)CCC1=O)ON1C(=O)CCC1=O | 5kg | 342449122
eMolecules 16959-62-9 | methyl indolizine-2-carboxylate | Pharmablock | MFCD13178636 | 175.187 | C10H9NO2 | 97.000 | COC(=O)c1cc2ccccn2c1 | 25mg | 788527012
methyl indolizine-2-carboxylate | Pharmablock | 16959-62-9 | MFCD13178636 | 175.187 | C10H9NO2 | 97.000 | COC(=O)c1cc2ccccn2c1 | 25mg | 788527012
Medchemexpress LLC Lodoxamide (U-42585E free acid) | 53882-12-5 | 98.1% | C11H6ClN3O6 | 200 MG
Lodoxamide (U-42585E free acid) is an antiallergic compound that acts as a mast-cell stabilizer, used for the treatment of asthma and allergic conjunctivitis.
- Inhibits histamine release and calcium influx in mast cells.
- Reduces chemotactic response of eosinophils to fMLP and IL-5.
- Inhibits eosinophil peroxidase release after IgA-dependent activation.
- Demonstrates cromolyn-like activity in mast cell assays and antigen-sensitized rhesus monkeys.
- Inhibits increased respiratory frequency and decreased tidal volume induced by antigen challenge.
- Reduces lung reperfusion injury in organ preservation solutions.
- Improves daytime breathing difficulty, cough, sputum, and sleep in patients.
eMolecules 939-16-2 | 3-Bromo-2-quinolinol | Combi-Blocks | MFCD00234482 | 224.057 | C9H6BrNO | 96.000 | Oc1nc2ccccc2cc1Br | 1g | 457920314
3-Bromo-2-quinolinol | Combi-Blocks | 939-16-2 | MFCD00234482 | 224.057 | C9H6BrNO | 96.000 | Oc1nc2ccccc2cc1Br | 1g | 457920314
Medchemexpress LLC B7-H2/ICOSLG protein, cynomolgus | >95.0% | 20 UG
B7-H2/ICOSLG protein (cynomolgus) is a recombinant extracellular domain of the ICOS ligand produced in HEK293 mammalian cells with a C-terminal His tag. Supplied lyophilized from PBS (pH 7.4), the protein is intended for immunology and receptor-ligand interaction studies and is characterized by low endotoxin and a defined amino acid range (M1-T256).
- Recombinant protein expressed in HEK293 mammalian cells.
- C-terminal His tag for purification and detection.
- Amino acid range M1-T256 corresponding to the extracellular domain.
- Observed molecular weight 50-70 kDa.
- Endotoxin <1 EU/μg (LAL method).
- Lyophilized formulation from PBS, pH 7.4; recommend aliquoting for storage.
Apexbio Technology LLC Isocytosine 108-53-2 200mg
Isocytosine (CAS 108-53-2) is a non-canonical nucleobase and a structural isomer of cytosine It serves as an analog in nucleic acid research notably as a component of expanded genetic systems such as hachimoji RNA and can pair with isoguanine to model non-standard base pairing Mechanistically isocytosine has been shown to modulate specific signaling pathways and enzyme activities in experimental systems It is widely utilized in molecular biology and genetics to investigate alternative base-pairing nucleic acid stability and the physicochemical properties of synthetic genetic polymers
Apexbio Technology LLC TAK-438 1260141-27-2 200mg
TAK-438 is a small-molecule inhibitor targeting gastric H K -ATPase It is designed to reversibly block potassium-competitive activity of this enzyme thereby suppressing gastric acid secretion TAK-438 exerts its biological activity primarily through direct potassium-competitive inhibition of the gastric H K -ATPase enzyme In animal studies TAK-438 demonstrates concentration-dependent inhibition of histamine-stimulated acid secretion in rats and dogs with effects persisting beyond 24 hours after oral administration Based on these pharmacological properties TAK-438 holds research potential in studies involving gastric acid physiology and acid-related gastrointestinal disorders
Apexbio Technology LLC Fasudil (HA-1077) HCl 105628-07-7 200mg
Fasudil HA-1077 HCl (CAS 105628-07-7) is a small-molecule inhibitor targeting Rho-associated protein kinase (ROCK) a serine/threonine kinase It is designed to inhibit ROCK thereby regulating cellular processes such as proliferation migration and apoptosis Fasudil HA-1077 HCl exerts its biological activity primarily through ROCK inhibition In cell-based studies Fasudil inhibits proliferation and migration and promotes apoptosis in cancer cell models including bladder carcinoma (5637 UM-UC-3) and oral squamous cell carcinoma (SCC-4) its ROCK inhibitory activity shows an IC50 value of approximately 0 74 M Based on these pharmacological properties Fasudil HA-1077 HCl holds research potential in oncology and disease models involving ROCK-mediated signaling